UFlorfenicol Sodium Succinate
Igama lomkhiqizo: UFlorfenicol sodium succinate

Izici zamakhemikhali:
Amhlophe noma amhlophe-anjenge-crystalline powder, awunamakha futhi awunambithi, lapho umswakama womoya ungaphezulu kokukhiqizwa Lo mkhiqizo unyibilikiswa kancane ku-acetone, ethanol, encibilikayo kalula emanzini, uqukethe i-florfenicol sodium muyine ayikho ngaphansi kwama-95%.

Isici Somkhiqizo:
1. IFlorfenicol sodium supplement yenza i-solubility yeFlorfenicol ibe ngu-300mg / ml futhi ingezwe izikhathi ezingama-400.
2. IFlorfenicol sodium ancidi yenza iFlorfenicol izinga lokuchithwa ngokushesha izikhathi ezingama-200, ngaphandle kokuncibilikisa, i-soluble instant emanzini
3. IFlorfenicol sodium anculile isuselwa kuFlorfenicol, emzimbeni yi-enzyme eyenziwe yafakwa kahle ku-florfenicol kanye nokuqina kwegazi okusebenzayo kwesikhathi eside.
4. Akudingi ukubamba iqhaza kwe-organic solvent kungasetjenziswa ekuphathweni kwemitholampilo, ukugwema imiphumela emibi yokusebenzisa i-solvent ye-organic (ukwenza ngcono ukuphepha komuthi, ukunciphisa izinsalela).

I-Pharmacology:
Lo mkhiqizo yi-Florfenicol derivatives, ngokuya ngemigomo yokuklanywa kwe -rodrug kwenze ukuthi kube namagciwane ahlukahlukene egram kanye ne-gram-negative futhi abambe iqhaza kwi-mycoplasma.
Umshini we-antibacterial unezakhi ezingama-50S ribosomal subunit, futhi uvimbela i-enzyme ebalulekile edingekayo ekwakhiweni kwamaprotheni - i-peptidyl transferase, engavimbela ngokuthe ngqo i-aminoacyl-tRNA ebopha ama-receptors entanjeni ye-ribosome inhibitory peptide enwetshiwe ishiya iprotheni ye-bacterium ingenakudalwa . Lo mkhiqizo ngeke wandise kuphela inqubo yawo yokuncibilikisa amanzi, kanye nomlomo kanye nokulimala ekulahlekelweni kwe-vivo, ngemuva kokuqothuka kwe-enzyme ekuwohlokeni komzimba kuma-esters ne-florfenicol ester ukunqoba ukumelana namagciwane. Ukugxila kweFlorfenicol, dlala izidakamizwa ezisebenza kakhulu ekusebenzeni komzimba, inani lincane, umphumela osheshayo, impilo ende, impilo ephezulu ye-plasma, isikhathi eside sokulungiselela ukugxilwa kwe-plasma. Ngokuyinhloko yi-excsotion yezinso.
 
Izinkomba
Kusetshenziswa enkukhu E. coli isifo kanye neSerositis nenhlanzi kubulala i-salmon Aeromonas, i-Vibrio straillarum yamagciwane abucayi ezinkomeni, izingulube, ukutheleleka kwamathumbu enkukhu kanye ne-mycoplasma okubangelwa ukuphefumula okungapheli.
 
Umthamo
Izinkukhu: isiphuzo esixubekile samanzi ayi-100L 3.5-4g, imfuyo, ngekhilogremu yesisindo somzimba esingu-20-25mg, kanye ngosuku bese usebenzisa izinsuku ezintathu. IM: izinkukhu, izingulube, izinkomo kanye nenani lesikhathi ngekhilogremu yesisindo somzimba esingu-15- 20mg, njalo ngama-48h ngasikhathi. Sebenzisa amahlandla amabili.