I-Procaine Benzylpenicillin evikelekile Yokulimala

Ukwakheka:
I-Eeach vial iqukethe:
Procaine penicillin bp ……………………… 3,000,000 iu
I-Benzylpenicillin sodium bp ………………… i-1,000,000 iu

Incazelo:
Umhlophe oyimpuphu noma omude-omhlophe.
Isenzo se-Pharmacological
IPenicillin iyi-antibiotic emincane ebamba ongezansi esebenza ngamagciwane ahlukahlukene egram kanye ne-cocci ezimbalwa ezingekho gram. Amagciwane abucayi abalulekile yi-staphylococcus, streptococcus, mycobacterium isifo sofuba, i-corynebacterium, i-clostridium tetanus, i-actinomycetes, i-bacillus anthracis, i-spirochetes, njll. ayizweli i-mycobacteria, mycoplasma, chlamydia, rickettsia, ne-rickettsia, i-rickettsia, ne-rickettsia, i-chlamydia, i-rickettsia, i-rumptsia, i-chlamydia, ne-rickettsia, i-rumptsia, i-chlamydia kanye ne-rickettsia. i-pharmacokinetics ngemuva komjovo we-proteine ​​we-procaine penicillin, umunca kancane ngemuva kokukhipha i-penicillin yi-hydrolysis yendawo. isikhathi esiphakeme sisekude, ukugxilisa kwegazi kuphansi, kepha umphumela mude kune-penicillin. kukhawulelwe kuma-pathogen azwela kakhulu i-penicillin futhi akufanele asetshenziselwe ukwelapha izifo ezimbi. ngemuva kokuthi i-procaine penicillin ne-penicillin sodium (potassium) ihlanganiswe nomjovo, ukuhlushwa kwegazi kungangezelwa esikhathini esifushane, kunikeze imiphumela yokuthatha isikhathi eside nokwenza okusheshayo. inani elikhulu lomjovo we-procaine penicillin kungadala ubuthi be-procaine.

I-Pharmacodynamics penicillin iyi-bactericidal antibiotic enemisebenzi eqinile ye-antibacterial. indlela elwa ngayo ne-antibacterial ngokuyinhloko ukuvimbela ukwakheka kwe-bacterius odongeni lwe-peptidoglycan. amagciwane abucayi esigabeni sokukhula ahlukaniswe ngamandla, futhi udonga lweseli lusesigabeni se-biosynthesis. ngaphansi kwesenzo se-penicillin, ukwakheka kwe-peptidoglycan kuvinjiwe futhi nodonga lweseli alunakwakhiwa, futhi ulwelwesi lweseli luqhekekile futhi lufe ngaphansi kwesenzo sokucindezela kwe-osmotic.

IPenicillin iyi-antibiotic emincane ebamba ongezansi esebenza ngamagciwane ahlukahlukene egram kanye ne-cocci ezimbalwa ezingekho gram. Amagciwane abucayi abalulekile yi-staphylococcus, streptococcus, mycobacterium isifo sofuba, i-corynebacterium, i-clostridium tetanus, i-actinomycetes, i-bacillus anthracis, i-spirochetes, njll. ayizweli i-mycobacteria, mycoplasma, chlamydia, rickettsia, ne-rickettsia, i-rickettsia, ne-rickettsia, i-chlamydia, i-rickettsia, i-rumptsia, i-chlamydia, ne-rickettsia, i-rumptsia, i-chlamydia kanye ne-rickettsia.
i-pharmacokinetics ngemuva komjovo we-proteine ​​we-procaine penicillin, umunca kancane ngemuva kokukhipha i-penicillin yi-hydrolysis yendawo. isikhathi esiphakeme sisekude, ukugxilisa kwegazi kuphansi, kepha umphumela mude kune-penicillin. kukhawulelwe kuma-pathogen azwela kakhulu i-penicillin futhi akufanele asetshenziselwe ukwelapha izifo ezimbi. ngemuva kokuthi i-procaine penicillin ne-penicillin sodium (potassium) ihlanganiswe nomjovo, ukuhlushwa kwegazi kungangezelwa esikhathini esifushane, kunikeze imiphumela yokuthatha isikhathi eside nokwenza okusheshayo. inani elikhulu lomjovo we-procaine penicillin kungadala ubuthi be-procaine.

Ukusebenzisana kwezidakamizwa
1. I-penicillin ehlanganiswe ne-aminoglycosides ingakhulisa ukugxila kokugcina kubhaktheriya, ngakho-ke inomphumela we-synergistic. 
2. Ama-bacteriostatic agents asebenza ngokushesha njengama-macrolides, ama-tetracyclines nama-amide alcohols anomthelela wokuphazamiseka emsebenzini we-bactericidal we-penicillin futhi akufanele usetshenziswe ndawonye. 
3. Ama-ion anensimbi esindayo (ikakhulukazi ithusi, i-zinc, i-mercury), i-alcohols, i-asidi, iodine, i-oxidants, ama-ejenti okunciphisa, i-hydroxy compounds, umjovo we-acid glucose noma umjovo we-tetracycline hydrochloride ungabhubhisa umsebenzi we-penicillin, okuwukuphikisana. 
4. Ama-amine nama-penicillin angakha usawoti ongabonakali, oguqula ukumunwa. lokhu kusebenzisana kungabambezela ukumuncwa kwe-penicillin, njenge-procaine penicillin. 
5. Futhi ezinye izixazululo zezidakamizwa (ezifana ne-chlorpromazine hydrochloride, i-lincomycin hydrochloride, i-norepinephrine tartrate, i-oxytetracycline hydrochloride, i-tetracycline hydrochloride, amavithamini we-b ne-Vitamin c) akufanele ixubeke, kungenjalo ingakhiqiza i-turbidity, floc noma i-precipitation.

Izinkomba
Kusetshenziselwa ikakhulukazi ukutheleleka okungamahlalakhona okubangelwa ama-bacterium abhekene ne-penicillin, njenge-pus esibelethweni sezinkomo, i-mastitis, ama-fractures ayinkimbinkimbi, njll., Futhi asetshenziselwa izifo ezibangelwa ama-actinomycetes ne-leptospira.
ukusetshenziswa nomthamo
Ngomjovo we-intramuscular. 
Umthamo owodwa, ngesisindo somzimba we-kg, amayunithi ayi-10,000 kuye kwangama-20,000 amahhashi nezinkomo; Amayunithi angama-20,000 kuya kwangama-30,000 ezimvu, izingulube, izimbongolo nethole; Amayunithi angama-30,000 kuya kwangama-40,000 izinja namakati. kanye nsuku zonke, izinsuku ezingama-2-3. 
engeza inani elifanelekile lamanzi angenazinkinga zokujova ukuze wenze ukumiswa ngaphambi kokuwusebenzisa.

Ukuphendula Okungalungile
1. Ukusabela okuyinhloko ukusabela kwe-allergic, okungenzeka emfuyweni eminingi, kepha izehlakalo ziphansi. ukusabela kwendawo kubonakaliswa yi-edema nobuhlungu esakhiweni somjovo, futhi ukusabela oku-systemic yi-urticaria kanye nokuqhuma. ezimweni ezinzima, kungadala ukushaqeka noma ukufa. 
2. Kwezinye izilwane, kungafaka ukutheleleka okuphindwe kabili kwepheshana lesisu.

Izeluleko
1. Lo mkhiqizo usetshenziselwa kuphela ukwelapha izifo ezingalapheki ezibangelwa amagciwane azwela kakhulu.
2. Iyancibilika kancane emanzini. lapho uthintana ne-acid, i-alkali noma i-oxidant, izolahlekelwa usizo ngokushesha. Ngakho-ke, umjovo kufanele ulungiswe ngaphambi kokusetshenziswa.
3. Nakisisa ukusebenzisana nokungasebenzelani nezinye izidakamizwa, ukuze kungathinti ukusebenza ngempumelelo.
isikhathi sokuhoxa
Izinkomo, izimvu nezingulube: 28days; 
Ubisi: amahora angama-72.

Isitoreji:
Kuvaliwe futhi kugcinwe endaweni eyomile.